Together we share ideas and spark connections between libraries, their collections and their people. Dr Eyad Elyan, Reader, School of Computing gives a presentation how businesses and industries can take advantage of AI solutions to inform decision making processes and provide a more efficient working environment. This video will provide some practical advice for how organisations can take effective steps to protect themselves from reputational harm during the pandemic, using established crisis communication principles and techniques. This video will explore the key traits of Generation Z and consider how employers can capitalise on the many positive contributions this new generation will bring to our workforce. This video provides an overview of Knowledge Transfer Partnerships , the new Management KTP scheme, and how the North of Scotland KTP Centre can help you secure funding. Participants will be encouraged to explore ways to overcome imposter syndrome both within themselves and within the teams and/or organisations that they lead.
You can read a number of resources including frequently asked questions and detailed information about the mathematical calculations used by the KEF dashboard. As most KTPs are full time roles, it can be difficult to juggle the demands of completing a course or submitting a thesis, so these need to be completed before the likely start date of a KTP graduate role. If your partnership is successful you will then receive a formal grant offer letter. You will normally be notified of the outcome within 12 weeks or less of the competition closing. Check to see if your university, college, research and technology organisation or catapult is listed on ourfind local advicepage. Working with your academic partner you will improve your business processes and performance, helping you to become more competitive and productive.
Research England assumed responsibility of the KEF in 2018 and the first results were published in March 2021. Information and resources to support you with Knowledge Exchange and engagement with external organisations. The Living Knowledge Network is a UK-wide partnership of national and public libraries.
In addition, classroom only and practical research degrees incur different charges. Submit questions about how to become an IB World School or enquire about our professional development opportunities. TOK is part of the International Baccalaureate® Diploma Programme core, and is mandatory for all students.
Moreover, autophagy seems to be linked also to cancer; however, this relationship is still controversial. The removal of mitochondria, source of reactive oxygen species , performed by autophagy, certainly protects cells from DNA mutations and prevents cellular transformation. It has also been demonstrated that deletion of the autophagic gene Beclin-1 may cause development of various malignancies in https://www.wikipedia.org/ mouse models . Autophagy is also involved in the degradation of intracellular pathogens, which represent a source of proteins involved in tumorigenesis . Despite its role in the maintenance of genomic stability, many studies indicate a tumor-supporting function of autophagy, allowing tumor cells to respond to stress stimuli, such as nutrients deficiency and hypoxia, thus extending their lifespan.
Two current Graduate Apprentices share their experiences of working and studying for a degree at the same time. Consider the step-by-step process for developing and delivering a virtual event and outlining practical ways of engaging an online audience. In this video, Professor Adam Ogilvie-Smith shares some thoughts on communicating and leading change in organisations. This video takes a look at the energy transition and the scale of the challenge; the timing of the necessary transition and how governments might engage business to make it work commercially. This video will explore some of the tools and techniques used to effectively manage a hybrid team; where some are working in the physical office space and others are working remotely. RGU’s ‘Runway to COP26’ represents a variety of sustainability-focussed activities and initiatives with emphasis on supporting the key themes of the milestone UN COP26 Conference.
Summary of the possible roles of autophagy in the pathogenesis and progression of rheumatoid arthritis . Autophagy could prevent the development of autoimmunity scenario by eliminating intracellular pathogens and maintaining immune cells homeostasis, including regulation of immunological tolerance mechanisms. Peripheral immune cells play an important role in the perpetuation of autoimmunity https://www.factory-publishing.com/ by sustaining systemic inflammation status and by participating in the extension of joint destruction mechanisms. Many studies demonstrated that autophagy allows T and B lymphocytes to survive in conditions of nutrients deprivation or during stress stimuli . Mice lacking Atg5 do not survive and have a reduction of peripheral T cells, showing how autophagy is essential for their survival .
One of the most important apoptosis functions consists in the extinguishing of inflammation, by blocking an excessive immune cells activation and cytokines production. In this regard, a reduction of apoptosis rate and apoptotic mediators was found at the synovial level, indicating a downregulation of apoptosis in RA . In fact, RA synovial fibroblasts are subjected to a complex pattern of molecular changes, including alterations in the expression of signaling pathways that lead to an aggressive and invasive phenotype .
Shen et al. showed that the induction of autophagy by rapamycin blocked the dexamethasone-induced apoptosis in meniscal cells, while the treatment with the autophagy inhibitor 3-MA increased the number of apoptotic cells . According to these results, other studies on condrocytes suggest a beneficial effect on bone loss by induction of autophagy contrasting glucocorticoid-induced apoptosis . Although for many years the role of Th1 cells has been considered predominant in RA, recently, a crucial role of Th17 cells is also emerging . This cell subset is a primary source of the pro-inflammatory cytokine IL-17, which acts in synergy with TNF-α and IL-1, contributing to the bone destruction. Most recent findings suggest a possible involvement of autophagy in osteoclastogenesis.