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Knowledge Exchange

Posted on May 25, 2022 by jimmy

The aim of the KEF is to increase efficiency and effectiveness in the use of public funding for knowledge exchange and to further a culture of continuous improvement in universities. It will allow universities to better understand and improve their own performance, as well as provide businesses and other users with more information to help them access the world-class knowledge and expertise embedded in English Higher Education Providers https://www.factory-publishing.com/ . You can use the knowledge exchange framework to explore data and explanations of the different ways universities collaborate with external partners, from businesses to community groups, for the benefit of the economy and society. Right now, around 800 businesses, 100 knowledge bases and over 800 graduates are involved in KTPs in our unique collaborative, three-way partnerships creating positive impact and driving innovation.

Since cytoplasmic calcium levels are essential for TCR-signaling pathways activation, autophagy-dependent calcium flux regulation could influence T lymphocytes activation. It has been demonstrated that CD4+ and CD8+ Atg5−/− cells are not able to properly proliferate following TCR stimulation . In fact, deletion of Atg7 results in decreased in IL-2 mRNA level and ATP generation, suggesting that autophagy is required to ensure appropriate energy level for T cell activation . Similar data were obtained also on B lymphocytes, demonstrating that autophagy is essential for the maturation process and for the subsequent maintenance of B lymphocytes repertoire in the periphery . Studies on the role of autophagy in lymphocytes isolated from RA patients are scarce and yet contradictory.

KTP typically pays 67% of project costs for micro, small and medium-sized businesses and 50% for large businesses. A suitably qualified graduate, with the capability to lead a strategic business project. The seminars are free to attend and are open to staff, students, alumni and the public. For booking instruction for non-UCL attendees, please view the individual event pages. The London Knowledge lab was led since 2004 by Professors Richard Noss and Alex Poulovassilis as a collaborative initiative between educators from IOE and computer scientists from Birkbeck, funded by the Science Research Investment Fund.

As already discussed, family members of Bcl-2, well known as apoptosis regulators, are able to modulate also autophagy by inhibition of Beclin-1 . It has been demonstrated that caspase-dependent cleavage of Beclin-1 and its subsequent localization to mitochondria promotes the release of proapoptotic factors from these organelles . The balance between cell survival and cell death is essential in regulating immune cells destiny and it seems to have a crucial role in RA pathogenesis and progression.

The progressive bone and cartilage destruction is attributable to resistance of synovial fibroblasts to apoptosis induction, and several intracellular processes, including autophagy, could take part in this phenomenon . As already discussed, there is a controversial crosstalk between autophagy and apoptosis; autophagy induction could be a potential mechanism by which RA cells protect themselves from apoptosis, increasing thus their lifespan. In support of this hypothesis, ER stress caused higher autophagy activation in synovial fibroblasts obtained from https://www.wikipedia.org/ patients with RA than in those from osteoarthritis patients, and RA-fibroblast-like synoviocytes appeared to be more resistant to cell death induction . Moreover, an inverse correlation between autophagy and apoptosis in synovial tissues from RA patients was found, indicating an involvement of autophagy in the apoptosis-resistant phenotype of RA synoviocytes . Recently, immune-histochemical and molecular analysis of autophagy-related molecules on synovial biopsies showed increased levels of Beclin1, Atg5, and LC3-II in RA compared to OA patients .

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