A KTP project can last between 12 and 36 months, depending on what the the challenge and the needs of the business. We will then notify you to say if we are interested in receiving your submission, and will at that stage provide you with further guidance and our submission requirements. We are happy to correspond in English, French and Spanish and have some capacity to respond in Arabic. Our Aquatic Research Facility is carrying out work with organisations across the globe to make corals more resilient in the face of man-made afflictions. Dependent on the research being carried out students will work differently in terms of location and the equipment they use. To deliver on their research milestones students will need to regularly work within the University research environment and with their research supervisory team.
The aim of the KEF is to increase efficiency and effectiveness in the use of public funding for knowledge exchange and to further a culture of continuous improvement in universities. It will allow universities to better understand and improve their own performance, as well as provide businesses and other users with more information to help them access the world-class knowledge and expertise embedded in English Higher Education Providers . You can use the knowledge exchange framework to explore data and explanations of the different ways universities collaborate with external partners, from businesses to community groups, for the benefit of the economy and society. Right now, around 800 businesses, 100 knowledge bases and over 800 graduates are involved in KTPs in our unique collaborative, three-way partnerships creating positive impact and driving innovation.
Supporting policy makers and practitioners across the UK in intelligence gathering, research and dissemination. The research and intelligence arm of the Idox group, a major supplier of software solutions and services to the UK public sector. Completing the CAPTCHA proves you are a human and gives you temporary access to the web property.
The progressive bone and cartilage destruction is attributable to resistance of synovial fibroblasts to apoptosis induction, and several intracellular processes, including autophagy, could take part in this phenomenon . As already discussed, there is a controversial crosstalk between autophagy and apoptosis; autophagy induction could be a potential mechanism by which RA cells protect themselves from apoptosis, increasing thus their lifespan. In support of this hypothesis, ER stress caused higher autophagy activation in synovial fibroblasts obtained from https://www.factory-publishing.com/ patients with RA than in those from osteoarthritis patients, and RA-fibroblast-like synoviocytes appeared to be more resistant to cell death induction . Moreover, an inverse correlation between autophagy and apoptosis in synovial tissues from RA patients was found, indicating an involvement of autophagy in the apoptosis-resistant phenotype of RA synoviocytes . Recently, immune-histochemical and molecular analysis of autophagy-related molecules on synovial biopsies showed increased levels of Beclin1, Atg5, and LC3-II in RA compared to OA patients .
Since cytoplasmic calcium levels are essential for TCR-signaling pathways activation, autophagy-dependent calcium flux regulation could influence T lymphocytes activation. It has been demonstrated that CD4+ and CD8+ Atg5−/− cells are not able to properly proliferate following TCR stimulation . In fact, deletion of Atg7 results in decreased in IL-2 mRNA level and ATP generation, suggesting that https://www.wikipedia.org/ autophagy is required to ensure appropriate energy level for T cell activation . Similar data were obtained also on B lymphocytes, demonstrating that autophagy is essential for the maturation process and for the subsequent maintenance of B lymphocytes repertoire in the periphery . Studies on the role of autophagy in lymphocytes isolated from RA patients are scarce and yet contradictory.
This webinar recording provides a demonstration of the NDC Partnership’s Knowledge Portal, which draws together the most relevant resources from leading institutions on climate mitigation and adaptation. At FMR, we are committed to examining our own practices and processes in order to take practical steps to be part of the change we want to see. DE-Carbonising The Region ‘DE-Carbonise’ is our most recent collaboration with Derby City and Derbyshire County Councils. Covid Collaboration with NHS and Riverside Medical Packaging During the pandemic, our research engineers have been working with local NHS trusts and Riverside Medical Packaging Ltd, to design and manufacture face shields for healthcare staff. Scaling-up If you’re ready to grow your business, see what support and funding we can offer. Join us at an Open Event to meet our expert academics and find out more about postgraduate opportunities.