In this regard, drugs that downregulate autophagy may be used to prevent bone resorption in RA patients. A future therapeutic approach based on autophagy suppression in RA might include 3-MA, a chemical compound that inhibits autophagy at an early stage of autophagosome formation, blocking the signaling of PI3K. This pathway has been used in experiments to analyze how autophagy inhibition can lead to beneficial effect in RA, including reduction of citrullinated peptides presentation and the reactivation of apoptosis pathways . Data on the systemic effect of 3-MA are limited, but a recent study showed an atheroprotective role of 3-MA, probably related to a downregulation of inflammation, in ApoE-deficient mice . Through postgraduate doctoral programmes such as a PhDs, companies can work alongside the University in industry funded studentships to develop research outcomes and new research specialists are trained. The University has a flexible approach to matching models of funding and … Read More
